Estelle Brodman, PhD (1914-2007), remains one of the most illustrious and revered health sciences librarian leaders of all time, widely respected for her intellect, knowledge, publications, teaching, and mentoring. The genesis of this special focus issue was a proposal prepared by T. Mark Hodges, representing the Fellows of the Medical Library Association, and based on discussions between Hodges and Lucretia W. McClure, AHIP, FMLA. Dr. Brodman had great influence on health sciences librarianship in all her roles-librarian, historian, educator, consultant, teacher, and mentor. She was widely admired and received many honors throughout her career. Her scholarly record and prescient ideas about health sciences librarianship have stood the test of time, and this focus issue honors her enduring legacy by exploring aspects of her long and distinguished career through the authors’ personal recollections and thoughts on Dr. Brodman’s contributions to the profession and her own oral history. The areas discussed include Dr. Brodman’s impact on library technology, her focus on education, her emphasis on international initiatives, and her role as a historian. An accompanying guest editorial completes the portrait of an extraordinary health sciences librarian.